Article
Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
BMC cancer - 10 Jun 2010
Nisa Hoirun, Kono Suminori, Yin Guang, Toyomura Kengo, Nagano Jun, Mibu Ryuichi, Tanaka Masao, Kakeji Yoshihiro, Maehara Yoshihiko, Okamura Takeshi, Ikejiri Koji, Futami Kitaroh, Maekawa Takafumi, Yasunami Yohichi, Takenaka Kenji, Ichimiya Hitoshi, Terasaka Reiji
Abstract excerpt
BACKGROUND: It is uncertain whether smoking is related to colorectal cancer risk. Cytochrome P-450 CYP1A1, glutathione-S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are important enzymes in the metabolism of tobacco carcinogens, and functional genetic polymorphisms are known for these enzymes. We investigated the relation of cigarette smoking and related genetic polymorphisms to colorectal...
Topics
- Adenocarcinoma
- Adult
- Aged
- Asian People
- Case-Control Studies
- Colorectal Neoplasms
- Cytochrome P-450 CYP1A1
- Female
- Genetic Predisposition to Disease
- Glutathione Transferase