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Article

Somatic alterations, metabolizing genes and smoking in rectal cancer.

International journal of cancer - 1 Jul 2009

Curtin Karen, Samowitz Wade S, Wolff Roger K, Herrick Jennifer, Caan Bette J, Slattery Martha L

Abstract excerpt

Cigarette smoking has been identified as a risk factor for rectal cancer. Our investigation evaluates associations between active and passive smoking and TP53, KRAS2, and BRAF V600E mutations, microsatellite instability (MSI), and CpG Island Methylator Phenotype (CIMP) in rectal tumors. We examine how genetic variants of GSTM1 and NAT2 alter these associations in a population-based, case-control study of 750...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

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Source

Open in PubMed Open full text

Identifiers

PMID: 19358278
DOI: 10.1002/ijc.24338
PMCID: PMC2782655

Genes

NAT2
BRAF
GSTM1
MLH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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