Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Desmoglein-2 deficiency drives mitochondrial morphological remodeling in cardiomyocytes.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2026

Gonçalves Alexandre, Chen Elaine Zhelan, Rastegarpouyani Hosna, Araújo Fernandes Aurélia, Alves Inês N, Sequeira Vasco, Kwon Chulan, Chelko Stephen P, Landim-Vieira Maicon

Abstract excerpt

Pathogenic variants in desmoglein-2 (DSG2) are a major cause of arrhythmogenic cardiomyopathy (ACM), a disease plagued by ventricular arrhythmias, contractile dysfunction, myocardial inflammation, and fibrofatty remodeling. In addition, increasing evidence implicates mitochondrial dysfunction in DSG2-associated disease. However, whether mitochondrial remodeling occurs uniformly across ventricles remains less well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmogenic Right Ventricular Dysplasia
Share to Desmoglein 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Mice, Inbred C57BL

Share to Mitochondria, Heart

Share to Mitochondrial Dynamics

Share to Mitophagy

Share to Myocytes, Cardiac

Source

Identifiers

PMID: 42363865
DOI: 10.1152/ajpheart.00368.2026

Genes

DSG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Desmoglein-2 deficiency drives mitochondrial morphological remodeling in cardiomyocytes.PMID 42363865Read ↗

Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations.Semantic proximity Read ↗

Ser194Leu DSG2 mutation, associated with arrhythmogenic left ventricular cardiomyopathy and ventricular tachycardia.Semantic proximity Read ↗

Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVCSemantic proximity Read ↗

Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity.Semantic proximity Read ↗

Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in MiceSemantic proximity Read ↗

Comprehensive analysis of desmosomal protein remodelling identifies desmocollin-2 as potential biomarker for arrhythmogenic cardiomyopathySemantic proximity Read ↗

Desmoplakin Cardiomyopathy: Gene Dose-Dependent Myocardial Remodeling, Arrhythmias, and Premature Death.Semantic proximity Read ↗

PANoptosis is a prominent feature of desmoplakin cardiomyopathySemantic proximity Read ↗

Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.Semantic proximity Read ↗

Junctophilin-2 Regulates Mitochondrial MetabolismSemantic proximity Read ↗

Interleukin-1β Drives Disease Progression in Arrhythmogenic CardiomyopathySemantic proximity Read ↗

Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond DesmosomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.