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Article

Aberrant expression of alternative DNA polymerases: a source of mutator phenotype as well as replicative stress in cancer.

Seminars in cancer biology - 1 Oct 2010

Hoffmann Jean-Sébastien, Cazaux Christophe

Abstract excerpt

The cell life span depends on a subtle equilibrium between the accurate duplication of the genomic DNA and less stringent DNA transactions which allow cells to tolerate mutations associated with DNA damage. The physiological role of the alternative, specialized or TLS (translesion synthesis) DNA polymerases could be to favor the necessary "flexibility" of the replication machinery, by allowing DNA replication to...

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Identifiers

PMID: 20934518
DOI: 10.1016/j.semcancer.2010.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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