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Article

Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes.

PloS one - 28 Sept 2010

Coelho Pedro M B M, Salvador Armindo, Savageau Michael A

Abstract excerpt

BACKGROUND: The NADPH redox cycle plays a key role in antioxidant protection of human erythrocytes. It consists of two enzymes: glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase. Over 160 G6PD variants have been characterized and associated with several distinct clinical manifestations. However, the mechanistic link between the genotype and the phenotype remains poorly understood....

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Identifiers

PMID: 20927393
DOI: 10.1371/journal.pone.0013031
PMCID: PMC2946920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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