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Article

Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens.

PLoS medicine - 1 Feb 2017

Chu Cindy S, Bancone Germana, Moore Kerryn A, Win Htun Htun, Thitipanawan Niramon, Po Christina, Chowwiwat Nongnud, Raksapraidee Rattanaporn, Wilairisak Pornpimon, Phyo Aung Pyae, Keereecharoen Lily, Proux Stéphane, Charunwatthana Prakaykaew, Nosten François, White Nicholas J

Abstract excerpt

BACKGROUND: Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD heterozygous females, because of individual variation in the pattern of X-chromosome inactivation (Lyonisation) in erythroid cells, may have low G6PD activity in the majority of their erythrocytes, yet are...

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PMID: 28170391
DOI: 10.1371/journal.pmed.1002224
PMCID: PMC5295665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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