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Article

Ion binding to KcsA: implications in ion selectivity and channel gating.

Biochemistry - 9 Nov 2010

Renart M L, Triano I, Poveda J A, Encinar J A, Fernández A M, Ferrer-Montiel A V, Gómez J, González Ros J M

Abstract excerpt

Binding of K+ and Na+ to the potassium channel KcsA has been characterized from the stabilization observed in the heat-induced denaturation of the protein as the ion concentration is increased. KcsA thermal denaturation is known to include (i) dissociation of the homotetrameric channel into its constituent subunits and (ii) protein unfolding. The ion concentration-dependent changes in the thermal stability of the...

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Identifiers

PMID: 20925387
DOI: 10.1021/bi101235v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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