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Article

Potassium-selective block of barium permeation through single KcsA channels.

The Journal of general physiology - 1 Oct 2011

Piasta Kene N, Theobald Douglas L, Miller Christopher

Abstract excerpt

Ba(2+), a doubly charged analogue of K(+), specifically blocks K(+) channels by virtue of electrostatic stabilization in the permeation pathway. Ba(2+) block is used here as a tool to determine the equilibrium binding affinity for various monovalent cations at specific sites in the selectivity filter of a noninactivating mutant of KcsA. At high concentrations of external K(+), the block-time distribution is...

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Share to Barium
Share to Cell Membrane
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Permeability

Share to Potassium

Share to Potassium Channels, Voltage-Gated

Share to Quaternary Ammonium Compounds

Source

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Identifiers

PMID: 21911483
DOI: 10.1085/jgp.201110684
PMCID: PMC3182450

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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