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Article

Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.

Biophysical journal - 1 Jan 2005

Tikhonov Denis B, Zhorov Boris S

Abstract excerpt

A large body of experimental data on Na+ channels is available, but the interpretation of these data in structural terms is difficult in the absence of a high-resolution structure. Essentially different electrophysiological and pharmacological properties of Na+ and K+ channels and poor identity of their sequences obstruct homology modeling of Na+ channels. In this work, we built the P-loops model of the Na+...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15475578
DOI: 10.1529/biophysj.104.048173
PMCID: PMC1304997

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Source receipt: pubmed, retrieved 7 Sept 2026.

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