[Single nucleotide polymorphism in flanking region of miR-30c influences the maturing process of miR-30c in lung carcinoma].

doi:10.3760/cma.j.issn.0253-3766.2012.09.005

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Article

[Single nucleotide polymorphism in flanking region of miR-30c influences the maturing process of miR-30c in lung carcinoma].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Sept 2012

Chen Jia-ping, Liu Yao, Hu Zhi-bin, Shen Hong-bing

Abstract excerpt

OBJECTIVE: To investigate the effect of a common polymorphism rs928508(A/G) in flanking region of miR-30c on the expression of pri, pre and mature miR-30c, and discuss the effect of this polymorphism on the maturing process of miR-30c in lung carcinoma. METHODS: The pGL3-promoter-miR-30c-A and pGL3-promoter-miR-30c-G luciferase plasmids were created containing A or G allele of miR-30c flanking region. Taqman...

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PMID: 23159078
DOI: 10.3760/cma.j.issn.0253-3766.2012.09.005

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