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Article

Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension

1 Oct 2010

Abstract excerpt

RATIONALE: Pulmonary hypertension (PH) is a progressive disease with unclear etiology. The significance of autophagy in PH remains unknown. OBJECTIVES: To determine the mechanisms by which autophagic proteins regulate tissue responses during PH. METHODS: Lungs from patients with PH, lungs from mice exposed to chronic hypoxia, and human pulmonary vascular cells were examined for autophagy using electron microscopy...

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PMID: 20889906
DOI: 10.1164/rccm.201005-0746oc

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