GSK-3α-BNIP3 axis promotes mitophagy in human cardiomyocytes under hypoxia

Abstract excerpt

Dysregulated autophagy/mitophagy is one of the major causes of cardiac injury in ischemic conditions. Glycogen synthase kinase-3alpha (GSK-3α) has been shown to play a crucial role in the pathophysiology of cardiac diseases. However, the precise role of GSK-3α in cardiac mitophagy remains unknown. Herein, we investigated the role of GSK-3α in cardiac mitophagy by employing AC16 human cardiomyocytes under the condi...

Topics

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Cardiac Ischemia and Reperfusion
• Cardiovascular Function and Risk Factors
• Congenital heart defects research
• Mitochondrial Function and Pathology
• Parkinson's Disease Mechanisms and Treatments
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

8b73b098-ecd3-591c-9c8e-233daa70e648

DOI

10.1101/2024.05.24.595650