Article

Lung microvascular rarefaction impairs pulmonary gas exchange and exacerbates heart failure with preserved ejection fraction

2026-03-09

Abstract excerpt

<h4>Background</h4> Dyspnea and exercise intolerance are the primary clinical symptoms of heart failure. Heart failure patients experience frequent hypoxemic episodes, yet underlying mechanisms and relevance remain poorly understood. In a cohort of heart failure patients and multiple animal models, we identify pulmonary capillary rarefaction driven by excessive autophagy in endothelial cells as a novel mechanism...

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Literature Corpus work: bc55b0ff-dce4-59cc-b86c-83558752a53e
DOI: 10.64898/2026.03.05.709974

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