Article
PDGFRA activating mutations in gastrointestinal stromal tumors.
Science (New York, N.Y.) - 31 Jan 2003
Heinrich Michael C, Corless Christopher L, Duensing Anette, McGreevey Laura, Chen Chang-Jie, Joseph Nora, Singer Samuel, Griffith Diana J, Haley Andrea, Town Ajia, Demetri George D, Fletcher Christopher D M, Fletcher Jonathan A
Abstract excerpt
Most gastrointestinal stromal tumors (GISTs) have activating mutations in the KIT receptor tyrosine kinase, and most patients with GISTs respond well to Gleevec, which inhibits KIT kinase activity. Here we show that approximately 35% (14 of 40) of GISTs lacking KIT mutations have intragenic activation mutations in the related receptor tyrosine kinase, platelet-derived growth factor receptor alpha (PDGFRA). Tumors...
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