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Article

Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2009

Deaton Rebecca A, Gan Qiong, Owens Gary K

Abstract excerpt

There is clear evidence that the phenotypic modulation of smooth muscle cells (SMCs) contributes to the pathophysiology of vascular disease. Phenotypic modulation refers to the unique ability of SMCs to alter their phenotype in response to extracellular stimuli and is hallmarked by the loss of SMC marker gene expression. The transcription factor Krüppel-like factor 4 (KLF4) is a known powerful negative regulator...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19168719
DOI: 10.1152/ajpheart.01230.2008
PMCID: PMC2670704

Genes

KLF4
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle.PMID 19168719Read ↗

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