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Article

A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis.

Circulation research - 12 Nov 2004

Wamhoff B R, Hoofnagle M H, Burns A, Sinha S, McDonald O G, Owens G K

Abstract excerpt

A hallmark of smooth muscle cell (SMC) phenotypic switching in atherosclerotic lesions is suppression of SMC differentiation marker gene expression. Yet little is known regarding the molecular mechanisms that control this process. Here we show that transcription of the SMC differentiation marker gene SM22alpha is reduced in atherosclerotic lesions and identify a cis regulatory element in the SM22alpha promoter...

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Identifiers

PMID: 15486317
DOI: 10.1161/01.RES.0000147961.09840.fb

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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