Article
Set7 mediated interactions regulate transcriptional networks in embryonic stem cells.
Nucleic acids research - 2 Nov 2016
Tuano Natasha K, Okabe Jun, Ziemann Mark, Cooper Mark E, El-Osta Assam
Abstract excerpt
Histone methylation by lysine methyltransferase enzymes regulate the expression of genes implicated in lineage specificity and cellular differentiation. While it is known that Set7 catalyzes mono-methylation of histone and non-histone proteins, the functional importance of this enzyme in stem cel...
Topics
- Animals
- Ataxin-1
- Biomarkers
- Cell Differentiation
- Cell Line
- Cluster Analysis
- Embryonic Stem Cells
- Enzyme Activation
- Gene Expression Profiling
- Gene Expression Regulation
- Gene Regulatory Networks
- Histone-Lysine N-Methyltransferase
- Humans
- Mice
- Models, Biological
- Octamer Transcription Factor-3
- Phenotype
- SOXB1 Transcription Factors