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Article

PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy.

International immunopharmacology - 1 Dec 2010

Majorczyk Edyta, Pawlik Andrzej, Kuśnierczyk Piotr

Abstract excerpt

PTPN22 (protein tyrosine phosphatase non-receptor type 22) 1858C>T single-nucleotide polymorphism (SNP) is one of the genetic risk factors of rheumatoid arthritis (RA). However, its role in the response of RA patients to therapy is not known. We examined a possible association of this SNP with a response of RA patients to methotrexate (MTX) treatment. RA was diagnosed in 371 patients according to the American...

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Source

Identifiers

PMID: 20888443
DOI: 10.1016/j.intimp.2010.09.008

Genes

PTPN22
ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy.PMID 20888443Read ↗

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The +1858C/T PTPN22 gene polymorphism confers genetic susceptibility to rheumatoid arthritis in Mexican population from the Western Mexico.Semantic proximity Read ↗

The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material.Semantic proximity Read ↗

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The PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

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