The +1858C/T PTPN22 gene polymorphism confers genetic susceptibility to rheumatoid arthritis in Mexican population from the Western Mexico.

doi:10.1016/j.imlet.2012.05.007

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The +1858C/T PTPN22 gene polymorphism confers genetic susceptibility to rheumatoid arthritis in Mexican population from the Western Mexico.

Immunology letters - 1 Sept 2012

Torres-Carrillo Nora Magdalena, Ruiz-Noa Yeniley, Martínez-Bonilla Gloria Esther, Leyva-Torres Sergio Daniel, Torres-Carrillo Norma, Palafox-Sánchez Claudia Azucena, Navarro-Hernández Rosa Elena, Rangel-Villalobos Héctor, Oregón-Romero Edith, Muñoz-Valle José Francisco

Abstract excerpt

INTRODUCTION: Rheumatoid arthritis (RA) is a common autoimmune disease with a complex genetic background. The PTPN22 gene encodes lymphoid tyrosine phosphatase LYP, a potent negative regulator of T cell activation. Polymorphic variants of this gene have previously been associated with various autoimmune disorders. The +1858C/T single-nucleotide polymorphism (SNP) (rs2476601), in the exon 14 of the PTPN22 gene has...

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PMID: 22743847
DOI: 10.1016/j.imlet.2012.05.007

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PTPN22
ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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