PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.

doi:10.1016/j.imlet.2019.10.010

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Article

PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.

Immunology letters - 1 Dec 2019

Ghorban Khodayar, Ezzeddini Rana, Eslami Majid, Yousefi Bahman, Sadighi Moghaddam Bizhan, Tahoori Mohammad-Taher, Dadmanesh Maryam, Salek Farrokhi Amir

Abstract excerpt

INTRODUCTION: Rheumatoid arthritis (RA) is one of the most common prevalent autoimmune diseases. The 1858 C/T (rs2476601) single nucleotide polymorphism (SNP) within the PTPN22 gene has been associated with susceptibility to inflammatory based diseases in several populations. It is implicated that altered cytokine production has a potential pathogenic role in the development of RA. The aim of this work was to...

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PMID: 31669381
DOI: 10.1016/j.imlet.2019.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.PMID 31669381Read ↗

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