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Carboxypeptidase A6 in Zebrafish Development and Implications for VIth Cranial Nerve Pathfinding

24 Sept 2010

Abstract excerpt

Carboxypeptidase A6 (CPA6) is an extracellular protease that cleaves carboxy-terminal hydrophobic amino acids and has been implicated in the defective innervation of the lateral rectus muscle by the VIth cranial nerve in Duane syndrome. In order to investigate the role of CPA6 in development, in particular its potential role in axon guidance, the zebrafish ortholog was identified and cloned. Zebrafish CPA6 was...

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PMID: 20885977
DOI: 10.1371/journal.pone.0012967

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