Article
Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling.
The Journal of cell biology - 4 Sept 2017
Capurro Mariana, Izumikawa Tomomi, Suarez Philippe, Shi Wen, Cydzik Marzena, Kaneiwa Tomoyuki, Gariepy Jean, Bonafe Luisa, Filmus Jorge
Abstract excerpt
Autosomal-recessive omodysplasia (OMOD1) is a genetic condition characterized by short stature, shortened limbs, and facial dysmorphism. OMOD1 is caused by loss-of-function mutations of glypican 6 (GPC6). In this study, we show that GPC6-null embryos display most of the abnormalities found in OMOD1 patients and that Hedgehog (Hh) signaling is significantly reduced in the long bones of these embryos. The...
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