Article
Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish.
Disease models & mechanisms - 1 Mar 2013
Song Yang, Wang Molin, Mao Fei, Shao Ming, Zhao Baochang, Song Zhen, Shao Changshun, Gong Yaoqin
Abstract excerpt
Mutations in patatin-like phospholipase domain containing 6 (PNPLA6), also known as neuropathy target esterase (NTE) or SPG39, cause hereditary spastic paraplegia (HSP). Although studies on animal models, including mice and Drosophila, have extended our understanding of PNPLA6, its roles in neura...
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