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Article

Novel carboxypeptidase A6 (CPA6) mutations identified in patients with juvenile myoclonic and generalized epilepsy.

PloS one - 1 Jan 2015

Sapio Matthew R, Vessaz Monique, Thomas Pierre, Genton Pierre, Fricker Lloyd D, Salzmann Annick

Abstract excerpt

Carboxypeptidase A6 (CPA6) is a peptidase that removes C-terminal hydrophobic amino acids from peptides and proteins. The CPA6 gene is expressed in the brains of humans and animals, with high levels of expression during development. It is translated with a prodomain (as proCPA6), which is removed before secretion. The active form of CPA6 binds tightly to the extracellular matrix (ECM) where it is thought to...

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Source

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Identifiers

PMID: 25875328
DOI: 10.1371/journal.pone.0123180
PMCID: PMC4395397

Genes

CPA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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