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Article

Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases.

Developmental biology - 15 Apr 2011

Ploper Diego, Lee Hojoon X, De Robertis Edward M

Abstract excerpt

In Xenopus, dorsal-ventral (D-V) patterning can self-regulate after embryo bisection. This is mediated by an extracellular network of proteins secreted by the dorsal and ventral centers of the gastrula. Different proteins of similar activity can be secreted at these two poles, but under opposite transcriptional control. Here we show that Crescent, a dorsal protein, can compensate for the loss of Sizzled, a...

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Source

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Identifiers

PMID: 21295563
DOI: 10.1016/j.ydbio.2011.01.029
PMCID: PMC3088358

Genes

BMP1
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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