Article
dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells.
PLoS genetics - 23 Sept 2010
Ziosi Marcello, Baena-López Luis Alberto, Grifoni Daniela, Froldi Francesca, Pession Andrea, Garoia Flavio, Trotta Vincenzo, Bellosta Paola, Cavicchi Sandro, Pession Annalisa
Abstract excerpt
Genetic analyses in Drosophila epithelia have suggested that the phenomenon of "cell competition" could participate in organ homeostasis. It has been speculated that competition between different cell populations within a growing organ might play a role as either tumor promoter or tumor suppressor, depending on the cellular context. The evolutionarily conserved Hippo (Hpo) signaling pathway regulates organ size...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.