Article
Impact of CYP2C9 genetic polymorphism on warfarin dose requirements in Pakistani population.
Pakistan journal of pharmaceutical sciences - 1 Oct 2010
Siddiqi Aisha, Khan Dilshad Ahmad, Khan Farooq Ahmed, Naveed Abdul Khaliq
Abstract excerpt
Variations of cytochrome-P450 enzyme system (CYP2CP) are associated with impaired metabolism of warfarin. The objective of our study was to estimate the frequency of genetic and allelic variants of CYP2C9 in Punjabi population of Pakistan and their effects on warfarin dose requirement. One hundred and twenty unrelated Pakistani subjects belong to Punjab province, were randomly included from the registry of...
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