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Article

Clinical relevance of SKP2 alterations in metastatic melanoma.

Pigment cell & melanoma research - 1 Feb 2011

Rose Amy E, Wang Guimin, Hanniford Douglas, Monni Stefano, Tu Ting, Shapiro Richard L, Berman Russell S, Pavlick Anna C, Pagano Michele, Darvishian Farbod, Mazumdar Madhu, Hernando Eva, Osman Iman

Abstract excerpt

In this study, we investigated the mechanism(s) of altered expression of protooncogene SKP2 in metastatic melanoma and its clinical relevance in patients with metastatic melanoma. The genomic status of SKP2 was assessed in cell lines by sequencing, single nucleotide polymorphism array, and genomic PCR. Copy number status was then evaluated for concordance with SKP2 mRNA and protein expression. SKP2 protein was...

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Identifiers

PMID: 20883453
DOI: 10.1111/j.1755-148X.2010.00784.x
PMCID: PMC3341662

Genes

SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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