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Article

Functional analysis of RPS27 mutations and expression in melanoma.

Pigment cell & melanoma research - 1 May 2020

Floristán Alfredo, Morales Leah, Hanniford Douglas, Martinez Carlos, Castellano-Sanz Elena, Dolgalev Igor, Ulloa-Morales Alejandro, Vega-Saenz de Miera Eleazar, Moran Una, Darvishian Farbod, Osman Iman, Kirchhoff Tomas, Hernando Eva

Abstract excerpt

Next-generation sequencing has enabled genetic and genomic characterization of melanoma to an unprecedent depth. However, the high mutational background plus the limited depth of coverage of whole-genome sequencing performed on cutaneous melanoma samples make the identification of novel driver mutations difficult. We sought to explore the somatic mutation portfolio in exonic and gene regulatory regions in human...

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PMID: 31663663
DOI: 10.1111/pcmr.12841
PMCID: PMC7180098

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