Article
trpm7 regulation of in vivo cation homeostasis and kidney function involves stanniocalcin 1 and fgf23.
Endocrinology - 1 Dec 2010
Elizondo Michael R, Budi Erine H, Parichy David M
Abstract excerpt
The transient receptor potential melastatin 7 (trpm7) channel kinase is a primary regulator of magnesium homeostasis in vitro. Here we show that trpm7 is an important regulator of cation homeostasis as well as kidney function in vivo. Using zebrafish trpm7 mutants, we show that early larvae exhibit reduced levels of both total magnesium and total calcium. Accompanying these deficits, we show that trpm7 mutants...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.