Article
Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.
Developmental biology - 15 Feb 2014
Decker Amanda R, McNeill Matthew S, Lambert Aaron M, Overton Jeffrey D, Chen Yu-Chia, Lorca Ramón A, Johnson Nicolas A, Brockerhoff Susan E, Mohapatra Durga P, MacArthur Heather, Panula Pertti, Masino Mark A, Runnels Loren W, Cornell Robert A
Abstract excerpt
Transient receptor potential, melastatin-like 7 (Trpm7) is a combined ion channel and kinase implicated in the differentiation or function of many cell types. Early lethality in mice and frogs depleted of the corresponding gene impedes investigation of the functions of this protein particularly during later stages of development. By contrast, zebrafish trpm7 mutant larvae undergo early morphogenesis normally and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.