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Article

Atp7a determines a hierarchy of copper metabolism essential for notochord development.

Cell metabolism - 1 Aug 2006

Mendelsohn Bryce A, Yin Chunyue, Johnson Stephen L, Wilm Thomas P, Solnica-Krezel Lilianna, Gitlin Jonathan D

Abstract excerpt

The critical developmental and genetic requirements of copper metabolism during embryogenesis are unknown. Utilizing a chemical genetic screen in zebrafish, we identified small molecules that perturb copper homeostasis. Our findings reveal a role for copper in notochord formation and demonstrate a hierarchy of copper metabolism within the embryo. To elucidate these observations, we interrogated a genetic screen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16890543
DOI: 10.1016/j.cmet.2006.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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