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Article

Sox10 is required for systemic initiation of bone mineralization.

Development (Cambridge, England) - 15 Jan 2025

Gjorcheska Stefani, Paudel Sandhya, McLeod Sarah, Paulding David, Snape Louisa, Sosa Karen Camargo, Duan Cunming, Kelsh Robert, Barske Lindsey

Abstract excerpt

Heterozygous variants in SOX10 cause congenital syndromes affecting pigmentation, digestion, hearing, and neural development, primarily attributable to failed differentiation or loss of non-skeletal neural crest derivatives. We report here an additional, previously undescribed requirement for Sox10 in bone mineralization. Neither crest- nor mesoderm-derived bones initiate mineralization on time in zebrafish sox10...

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Share to Calcification, Physiologic
Share to Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neural Crest

Share to Osteoblasts

Share to SOXE Transcription Factors

Share to TRPV Cation Channels

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Source

Open in PubMed Open full text

Identifiers

PMID: 39791977
DOI: 10.1242/dev.204357
PMCID: PMC11833171

Genes

SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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