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Article

Does cytolysis by CD8+ T cells drive immune escape in HIV infection?

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2010

Balamurali Mehala, Petravic Janka, Loh Liyen, Alcantara Sheilajen, Kent Stephen J, Davenport Miles P

Abstract excerpt

CD8(+) "cytotoxic" T cells are important for the immune control of HIV and the closely related simian models SIV and chimeric simian-human immunodeficiency virus (SHIV), although the mechanisms of this control are unclear. One effect of CD8(+) T cell-mediated recognition of virus-infected cells is the rapid selection of escape mutant (EM) virus that is not recognized. To investigate the mechanisms of...

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Share to CD8-Positive T-Lymphocytes
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20881189
DOI: 10.4049/jimmunol.1002204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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