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Article

Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase

29 Sept 2010

Abstract excerpt

Hepatitis C virus (HCV) infects over 130 million people causing a worldwide epidemic of liver cirrhosis and hepatocellular-carcinoma. Because current HCV treatments are only partially effective, molecular mechanisms involved in HCV propagation are actively being pursued as possible drug targets. Here, we report on a new macromolecular interaction between the HCV capsid core protein and the helicase portion of HCV...

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PMID: 20881089
DOI: 10.1099/vir.0.023325-0

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