Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus.

Journal of virology - 1 Dec 2011

Jones Daniel M, Atoom Ali M, Zhang Xiaozhen, Kottilil Shyamasundaran, Russell Rodney S

Abstract excerpt

By analogy to other members of the Flaviviridae family, the hepatitis C virus (HCV) core protein is presumed to oligomerize to form the viral nucleocapsid, which encloses the single-stranded RNA genome. Core protein is directed to lipid droplets (LDs) by domain 2 (D2) of the protein, and this process is critical for virus production. Domain 1 (D1) of core is also important for infectious particle morphogenesis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluorescent Antibody Technique, Indirect
Share to Hepacivirus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis C

Share to Tumor Cells, Cultured

Share to Viral Core Proteins

Share to Viral Nonstructural Proteins

Share to Virion

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 21957313
DOI: 10.1128/JVI.05313-11
PMCID: PMC3209351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus.PMID 21957313Read ↗

HCV core residues critical for infectivity are also involved in core-NS5A complex formation.Semantic proximity Read ↗

The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.Semantic proximity Read ↗

A role for domain I of the hepatitis C virus NS5A protein in virus assemblySemantic proximity Read ↗

Alanine scanning of the hepatitis C virus core protein reveals numerous residues essential for production of infectious virus.Semantic proximity Read ↗

Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.Semantic proximity Read ↗

A Host YB-1 Ribonucleoprotein Complex Is Hijacked by Hepatitis C Virus for the Control of NS3-Dependent Particle ProductionSemantic proximity Read ↗

Core protein domains involved in hepatitis C virus-like particle assembly and budding at the endoplasmic reticulum membrane.Semantic proximity Read ↗

Identification of basic amino acids at the N-terminal end of the core protein that are crucial for hepatitis C virus infectivity.Semantic proximity Read ↗

Hepatitis C Virus: Assembly and Release of Virus ParticlesSemantic proximity Read ↗

Y-Box-Binding Protein 1 Interacts with Hepatitis C Virus NS3/4A and Influences the Equilibrium between Viral RNA Replication and Infectious Particle ProductionSemantic proximity Read ↗

The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein.Semantic proximity Read ↗

Structural biology of hepatitis C virusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.