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Article

Identification of residues involved in NS2 homodimerization and elucidation of their impact on the HCV life cycle.

Journal of viral hepatitis - 1 Mar 2012

Gorzin A A, Ramsland P A, Tachedjian G, Gowans E J

Abstract excerpt

The NS2 protein of hepatitis C virus (HCV) plays a critical role in virus morphogenesis and infectivity. The crystal structure of the C-terminus of the NS2 protein (NS2(Pro)) from the H77 strain indicates that NS2(Pro) forms a homodimer. In this study, using computational modelling, we identified residues at the NS2(Pro) dimer interface that have a role in dimerization and confirmed their capacity to influence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22329373
DOI: 10.1111/j.1365-2893.2011.01504.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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