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Article

Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase.

Journal of virology - 1 Jan 2001

Khu Y L, Koh E, Lim S P, Tan Y H, Brenner S, Lim S G, Hong W J, Goh P Y

Abstract excerpt

Interaction between viral proteins is necessary for viral replication and viral particle assembly. We used the yeast two-hybrid assay to identify interactions among all the mature proteins of the hepatitis C virus. The interaction between NS3 and NS3 was one of the strongest viral protein-protein interactions detected. The minimal region required for this interaction was mapped to a specific subdomain of 174...

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Identifiers

PMID: 11119590
DOI: 10.1128/JVI.75.1.205-214.2001
PMCID: PMC113914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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