Article
Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.
PLoS pathogens - 16 Dec 2010
Jirasko Vlastimil, Montserret Roland, Lee Ji Young, Gouttenoire Jérôme, Moradpour Darius, Penin Francois, Bartenschlager Ralf
Abstract excerpt
Non-structural protein 2 (NS2) plays an important role in hepatitis C virus (HCV) assembly, but neither the exact contribution of this protein to the assembly process nor its complete structure are known. In this study we used a combination of genetic, biochemical and structural methods to decipher the role of NS2 in infectious virus particle formation. A large panel of NS2 mutations targeting the N-terminal...
Topics
- Hepacivirus
- Lipids
- Mutagenesis
- Mutation
- Protein Binding
- Protein Transport
- Viral Nonstructural Proteins
- Virion
- Virus Assembly