Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular modeling of mechanosensory ion channel structural and functional features.

PloS one - 16 Sept 2010

Gessmann Renate, Kourtis Nikos, Petratos Kyriacos, Tavernarakis Nektarios

Abstract excerpt

The DEG/ENaC (Degenerin/Epithelial Sodium Channel) protein family comprises related ion channel subunits from all metazoans, including humans. Members of this protein family play roles in several important biological processes such as transduction of mechanical stimuli, sodium re-absorption and blood pressure regulation. Several blocks of amino acid sequence are conserved in DEG/ENaC proteins, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channels

Share to Mechanotransduction, Cellular

Share to Models, Molecular

Share to Protein Conformation

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 20877470
DOI: 10.1371/journal.pone.0012814
PMCID: PMC2943245

Genes

ASIC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular modeling of mechanosensory ion channel structural and functional features.PMID 20877470Read ↗

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.Semantic proximity Read ↗

Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.Semantic proximity Read ↗

Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human DiseasesSemantic proximity Read ↗

The genetic architecture of degenerin/epithelial sodium channels in Drosophila.Semantic proximity Read ↗

Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8.Semantic proximity Read ↗

Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.Semantic proximity Read ↗

Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases.Semantic proximity Read ↗

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex.Semantic proximity Read ↗

Function and phylogeny support the independent evolution of acid-sensing ion channels in the PlacozoaSemantic proximity Read ↗

Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.Semantic proximity Read ↗

Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Semantic proximity Read ↗

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.