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Article

Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.

The Journal of general physiology - 1 Feb 2007

Brown Austin L, Fernandez-Illescas Silvia M, Liao Zhiwen, Goodman Miriam B

Abstract excerpt

MEC-4 and MEC-10 are the pore-forming subunits of the sensory mechanotransduction complex that mediates touch sensation in Caenorhabditis elegans (O'Hagan, R., M. Chalfie, and M.B. Goodman. 2005. Nat. Neurosci. 8:43-50). They are members of a large family of ion channel proteins, collectively termed DEG/ENaCs, which are expressed in epithelial cells and neurons. In Xenopus oocytes, MEC-4 can assemble into...

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Identifiers

PMID: 17261841
DOI: 10.1085/jgp.200609672
PMCID: PMC2154353

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.PMID 17261841Read ↗

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