Article

Function and phylogeny support the independent evolution of acid-sensing ion channels in the Placozoa

2022-06-30

Abstract excerpt

Acid-sensing ion channels (ASICs) are proton-gated cation channels that are part of the Deg/ENaC ion channel family, which also includes neuropeptide-, bile acid-, and mechanically-gated channels. Despite sharing common tertiary and quaternary structures, strong sequence divergence within the Deg/ENaC family has made it difficult to resolve their phylogenetic relationships, and by extension, whether channels with...

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Literature Corpus work: f6055e49-356e-54cb-b9a7-cf17255fb1ff
DOI: 10.1101/2022.06.28.497943

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