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Article

Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8.

American journal of physiology. Cell physiology - 1 Aug 2018

Matthewman Cristina, Johnson Christina K, Miller David M, Bianchi Laura

Abstract excerpt

UNC-8 and MEC-4 are two members of the degenerin/epithelial Na+ channel (DEG/ENaC) family of voltage-independent Na+ channels that share a high degree of sequence homology and functional similarity. For example, both can be hyperactivated by genetic mutations [UNC-8(d) and MEC-4(d)] that induce neuronal death by necrosis. Both depend in vivo on chaperone protein MEC-6 for function, as demonstrated by the finding...

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Identifiers

PMID: 29694233
DOI: 10.1152/ajpcell.00297.2017
PMCID: PMC6139502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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