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Article

The imprinted gene Magel2 regulates normal circadian output.

Nature genetics - 1 Oct 2007

Kozlov Serguei V, Bogenpohl James W, Howell Maureen P, Wevrick Rachel, Panda Satchin, Hogenesch John B, Muglia Louis J, Van Gelder Russell N, Herzog Erik D, Stewart Colin L

Abstract excerpt

Mammalian circadian rhythms of activity are generated within the suprachiasmatic nucleus (SCN). Transcripts from the imprinted, paternally expressed Magel2 gene, which maps to the chromosomal region associated with Prader-Willi Syndrome (PWS), are highly enriched in the SCN. The Magel2 message is circadianly expressed and peaks during the subjective day. Mice deficient in Magel2 expression entrain to light cycles...

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Identifiers

PMID: 17893678
DOI: 10.1038/ng2114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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