Article

Investigation of a Novel Mouse Model of Prader-Willi Syndrome with Invalidation of <i>Necdin</i> and <i>Magel2</i>

2024-07-24

Abstract excerpt

Prader-Willi syndrome (PWS) is a multigenic disorder caused by the loss of seven contiguous paternally expressed genes. Mouse models with inactivation of all PWS genes are lethal. Knockout (KO) mouse models for each candidate gene were generated, but they lack the functional interactions between PWS genes. Here, we revealed an interplay between Necdin and Magel2 “PWS” genes and generated a novel mouse model (nam...

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Literature Corpus work: a2032d55-564b-5025-9954-dd0e05b45901
DOI: 10.1101/2024.07.24.604909

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