Article
The impact of tissue block sampling on the detection of p53 signatures in fallopian tubes from women with BRCA 1 or 2 mutations (BRCA+) and controls.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2011
Mehra Karishma K, Chang Martin C, Folkins Ann K, Raho Caroline J, Lima Joema F, Yuan Liping, Mehrad Mitra, Tworoger Shelley S, Crum Christopher P, Saleemuddin Aasia
Abstract excerpt
The tubal p53 signature is a putative precursor to pelvic serous carcinoma, but its frequencies in women with inherited mutations in the BRCA1 or BRCA2 genes (BRCA+) and controls has been controversial. An initial section and two levels (100-200 μm) from every block in BRCA+ (24) and control tubes (40) were stained for p53. The frequency of p53 signatures was computed between the populations and across the three...
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