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Article

N-acetyl transferase 2 polymorphisms associated with isoniazid pharmacodynamics: molecular features for ligand interaction.

Anticancer research - 1 Aug 2010

Ohkura Kazuto, Fukino Katsumi, Shinohara Yasuo, Hori Hitoshi

Abstract excerpt

BACKGROUND: Isoniazid is mainly metabolized by arylamine N-acetyltransferase 2 (NAT2). Rapid acetylator types have NAT2*4/*4 alleles. Intermediate acetylator types have any of the following alleles: NAT2*4/*5, *4/*6, or *4/*7. Slow acetylator types do not have the NAT2*4 allele. We examined molecular features of these NAT2 molecules. MATERIALS AND METHODS: Structures of NAT2*5, *6, and *7 were constructed based...

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Source

Identifiers

PMID: 20871037

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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N-acetyl transferase 2 polymorphisms associated with isoniazid pharmacodynamics: molecular features for ligand interaction.PMID 20871037Read ↗

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