Article
Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases.
The Journal of biological chemistry - 12 Oct 2007
Wu Hong, Dombrovsky Ludmila, Tempel Wolfram, Martin Fernando, Loppnau Peter, Goodfellow Geoffrey H, Grant Denis M, Plotnikov Alexander N
Abstract excerpt
The human arylamine N-acetyltransferases NAT1 and NAT2 play an important role in the biotransformation of a plethora of aromatic amine and hydrazine drugs. They are also able to participate in the bioactivation of several known carcinogens. Each of these enzymes is genetically variable in human populations, and polymorphisms in NAT genes have been associated with various cancers. Here we have solved the high...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.