Article
Structural basis for recognition of S-adenosylhomocysteine by riboswitches.
RNA (New York, N.Y.) - 1 Nov 2010
Edwards Andrea L, Reyes Francis E, Héroux Annie, Batey Robert T
Abstract excerpt
S-adenosyl-(L)-homocysteine (SAH) riboswitches are regulatory elements found in bacterial mRNAs that up-regulate genes involved in the S-adenosyl-(L)-methionine (SAM) regeneration cycle. To understand the structural basis of SAH-dependent regulation by RNA, we have solved the structure of its metabolite-binding domain in complex with SAH. This structure reveals an unusual pseudoknot topology that creates a...
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