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Article

S-adenosylmethionine directly inhibits binding of 30S ribosomal subunits to the SMK box translational riboswitch RNA.

Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2007

Fuchs Ryan T, Grundy Frank J, Henkin Tina M

Abstract excerpt

The S(MK) box is a conserved riboswitch motif found in the 5' untranslated region of metK genes [encoding S-adenosylmethionine (SAM) synthetase] in lactic acid bacteria, including Enterococcus, Streptococcus, and Lactococcus sp. Previous studies showed that this RNA element binds SAM in vitro, and SAM binding causes a structural rearrangement that sequesters the Shine-Dalgarno (SD) sequence by pairing with an...

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Identifiers

PMID: 17360376
DOI: 10.1073/pnas.0609956104
PMCID: PMC1829232

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S-adenosylmethionine directly inhibits binding of 30S ribosomal subunits to the SMK box translational riboswitch RNA.PMID 17360376Read ↗

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